Discontinuation of anti-VEGF cancer therapy promotes metastasis through a liver revascularization mechanism.

We thank Simcere Pharmaceuticals, Nanjing, China for providing a rabbit anti-VEGF neutralizing monoclonal antibody. Y.C.’s laboratory is supported through research grants from: the Swedish Research Council; the Swedish Cancer Foundation; the Karolinska Institute Foundation; the Karolinska Institute distinguished professor award; the Torsten Soderbergs Foundation; the Tore Nilsons Foundation; the Ruth and Richard Julin Foundation; the Ogonfonden Foundation; the Martin Rinds Foundation; the Maud and Birger Foundation; the Lars Hiertas Minne Foundation; the Alex and Eva Wallströms Foundation; the Robert Lundbergs Memorial Foundation; the Swedish Diabetes Foundation; the Swedish Children Cancer Foundation; the European Research Council (ERC) advanced grant ANGIOFAT (Project no 250021); the Knut Alice Wallenberg Foundation and the NOVO Nordisk Foundation for the advanced grant. The Lab in Shenzhen is supported by Shenzhen Science and Technology Innovation Committee (Projects no JCYJ 20150403091443336 and JCYJ 20150330102720136); Guangdong Science and Technology Department (project no 2014A020212654); Shenzhen finance committee (High level disciplinary development program for university-affiliated hospital); Municipal Development and Reform Commission (programme Shenzhen Auditognosis and Balancing Function Medical Technology Engineering Laboratory).