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Disease stage, but not sex, predicts depression and psychological distress in Huntington’s disease : A European population study

journal contribution
posted on 2015-12-07, 10:17 authored by Maria Dale, John Julian Maltby, S. Shimozaki, R. Cramp, H. Rickards, REGISTRY investigators of the European Huntington’s Disease Network
Objective Depression and anxiety significantly affect morbidity in Huntington’s disease. Mice models of Huntington’s disease have identified sex differences in mood-like behaviours that vary across disease lifespan, but this interaction has not previously been explored in humans with Huntington’s disease. However, among certain medical populations, evidence of sex differences in mood across various disease stages has been found, reflecting trends among the general population that women tend to experience anxiety and depression 1.5 to 2 times more than men. The current study examined whether disease stage and sex, either separately or as an interaction term, predicted anxiety and depression in Huntington’s disease. Methods A cross-sectional study of REGISTRY data involving 453 Huntington’s disease participants from 12 European countries was undertaken using the Hospital Anxiety and Depression Scale. A series of multiple regression analyses were undertaken to discover to what extent disease stage and sex predicted anxiety, depression, and general distress after controlling for a number of known predictors of mood difficulties. Results Disease stage, but not sex, was found to predict depressive symptoms and general distress. Neither disease stage nor sex predicted anxiety. Furthermore, an interaction term computed for disease stage and sex did not contribute to the models tested. Conclusion In terms of considering risks to developing depression and anxiety in the Huntington’s disease population, practitioners may need to pay special attention to disease stage progression (but not sex differences) to enable early detection and treatment of depression (but not anxiety).

History

Citation

Journal of Psychosomatic Research, 2016, 80, pp. 17–22

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/MBSP Non-Medical Departments/Neuroscience, Psychology and Behaviour

Version

  • AM (Accepted Manuscript)

Published in

Journal of Psychosomatic Research

Publisher

Elsevier for European Association for Consultation-Liaison Psychiatry and Psychosomatics

issn

0022-3999

eissn

1879-1360

Acceptance date

2015-11-11

Copyright date

2015

Available date

2016-11-12

Publisher version

http://www.sciencedirect.com/science/article/pii/S0022399915005759

Notes

The file associated with this record is under a 12-month embargo from publication in accordance with the publisher's self-archiving policy, available at https://www.elsevier.com/about/company-information/policies/sharing. The full text may be available through the publisher links provided above.

Editors

Levenson, J. L.

Language

en

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