University of Leicester
Browse
Dissociation of place preference and tolerance responses to sucrose using a dopamine antagonist in the planarian.pdf (661.03 kB)

Dissociation of place preference and tolerance responses to sucrose using a dopamine antagonist in the planarian.

Download (661.03 kB)
journal contribution
posted on 2018-04-23, 09:59 authored by Rafat A. Mohammed Jawad, Claire V. Hutchinson, Jose Prados
In rodents, sucrose has been found to elicit addictive-like behaviours like the development of tolerance and the association with cues present at the time of consumption. Furthermore, the neurochemical response to sucrose binges is equivalent to the one observed in response to the abuse of addictive substances like cocaine. The experiments reported here address the effects of sucrose on an invertebrate model, the Platyhelminth brown planarian. The animals exposed to a 10% sucrose solution in one context developed a conditioned place preference (CPP) which was subsequently extinguished in the absence of the rewarding agent. However, one exposure to sucrose per se sufficed to reinstate the CPP response, suggesting sucrose-induced CPP can be characterised as a standard Pavlovian response. The same training procedure led to the development of context-specific tolerance to the effects of sucrose. However, comparing animals treated with dopamine D1 antagonist (SCH-23390) with control animals showed that the establishment of CPP, but not the development of tolerance, is mediated by the dopamine reward system.

History

Citation

Psychopharmacology, 2018, 235 (3), pp. 829-836

Author affiliation

/Organisation/COLLEGE OF LIFE SCIENCES/Biological Sciences/Neuroscience, Psychology and Behaviour

Version

  • VoR (Version of Record)

Published in

Psychopharmacology

Publisher

Springer Verlag

issn

0033-3158

eissn

1432-2072

Copyright date

2018

Available date

2018-04-23

Publisher version

https://link.springer.com/article/10.1007/s00213-017-4801-8

Language

en

Usage metrics

    University of Leicester Publications

    Categories

    Licence

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC