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Dual role of complement in adipose tissue

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journal contribution
posted on 2009-07-15, 15:04 authored by Michael Pattrick, Jeni C. Luckett, Liang Yue, Cordula M. Stover
Once thought of as purely the body’s chief energy store, adipose tissue and its constituent adipocytes have emerged as both a metabolic entity and an endocrine one. Complement is generally thought of as originating mainly from hepatic synthesis but also from synthesis by the macrophage phagocyte system. This review revisits early descriptions of adipocytic synthesis of complement components and highlights the need of a systematic analysis of the contribution of adipose tissue to systemic inflammation in order to appreciate the immunological activity of this tissue.

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Citation

Molecular Immunology, 2009, 46 (5), pp. 755-760.

Published in

Molecular Immunology

Publisher

Elsevier

issn

0161-5890

Copyright date

2009

Available date

2009-07-15

Publisher version

http://www.sciencedirect.com/science/article/pii/S0161589008006676

Language

en

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