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ENO2, a Glycolytic Enzyme, Contributes to Prostate Cancer Metastasis: A Systematic Review of Literature

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posted on 2024-08-01, 13:41 authored by Yuhan Zhou, Feier Zeng, Gareth Owain Richards, Ning Wang
Prostate cancer (PCa) is the second leading cause of male cancer deaths in the UK and the fifth worldwide. The presence of distant PCa metastasis can reduce the 5-year survival rate from 100% to approximately 30%. Enolase 2 (ENO2), a crucial glycolytic enzyme in cancer metabolism, is associated with the metastasis of multiple cancers and is also used as a marker for neuroendocrine tumours. However, its role in PCa metastasis remains unclear. In this study, we systematically reviewed the current literature to determine the association between ENO2 and metastatic PCa. Medline, Web of Science, and PubMed were searched for eligible studies. The search yielded five studies assessing ENO2 expression in PCa patients or cell lines. The three human studies suggested that ENO2 expression is correlated with late-stage, aggressive PCa, including castrate-resistant PCa (CRPC), metastatic CRPC, and neuroendocrine PCa (NEPC). This was further supported by two in vitro studies indicating that ENO2 expression can be regulated by the tumour microenvironment, such as androgen deprived conditions and the presence of bone-forming osteoblasts. Therefore, ENO2 may functionally contribute to PCa metastasis, possibly due to the unique metabolic features of PCa, which are glycolysis dependent only at the advanced metastatic stage.

History

Author affiliation

College of Life Sciences Genetics & Genome Biology

Version

  • VoR (Version of Record)

Published in

Cancers

Volume

16

Issue

14

Pagination

2503

Publisher

MDPI AG

eissn

2072-6694

Copyright date

2024

Available date

2024-08-01

Language

en

Deposited by

Dr Ning Wang

Deposit date

2024-07-29

Data Access Statement

The data presented in this study are available in this article and Supplementary Materials.

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