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ERG Responses in Albinism, Idiopathic Infantile Nystagmus, and Controls

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posted on 2024-04-16, 13:45 authored by Zhanhan Tu, Christopher Degg, Michael Bach, Rebecca McLean, Viral Sheth, Mervyn G Thomas, Shangqing Yang, Irene Gottlob, Frank A Proudlock

Purpose

Our primary aim was to compare adult full-field ERG (ffERG) responses in albinism, idiopathic infantile nystagmus (IIN), and controls. A secondary aim was to investigate the effect of within-subject changes in nystagmus eye movements on ffERG responses.

Methods

Dilated Ganzfeld flash ffERG responses were recorded using DTL electrodes under conditions of dark (standard and dim flash) and light adaptation in 68 participants with albinism, 43 with IIN, and 24 controls. For the primary aim, the effect of group and age on ffERG responses was investigated. For the secondary aim, null region characteristics were determined using eye movements recorded prior to ffERG recordings. ffERG responses were recorded near and away from the null regions of 18 participants also measuring the success rate of recordings.

Results

For the primary aim, age-adjusted photopic a- and b-wave amplitudes were consistently smaller in IIN compared with controls (P < 0.0001), with responses in both groups decreasing with age. In contrast, photopic a-wave amplitudes increased with age in albinism (P = 0.0035). For the secondary aim, more intense nystagmus significantly reduced the success rate of measurable responses. Within-subject changes in nystagmus intensity generated small, borderline significant differences in photopic b-wave peak times and a-and b-wave amplitudes under scotopic conditions with standard flash.

Conclusions

Age-adjusted photopic ffERG responses are significantly reduced in IIN adding to the growing body of evidence of retinal abnormalities in IIN. Differences between photopic responses in albinism and controls depend on age. Success at obtaining ffERG responses could be improved by recording responses at the null region.

Funding

Optical coherence tomography in infants and children: A normative database and assessment of clinical use

Medical Research Council

Find out more...

Ultra-high resolution optical coherence tomography (UHR-SD OCT) in infants and children: characterisation of normal and abnormal foveal development

Medical Research Council

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Ulverscroft Foundation, Leicester, UK,

Nystagmus Network UK

History

Author affiliation

College of Life Sciences/Psychology & Vision Sciences

Version

  • VoR (Version of Record)

Published in

Investigative Opthalmology & Visual Science

Volume

65

Issue

4

Pagination

11 - 11

Publisher

Association for Research in Vision and Ophthalmology (ARVO)

issn

1552-5783

eissn

1552-5783

Copyright date

2024

Available date

2024-04-16

Spatial coverage

United States

Language

en

Deposited by

Dr Zhanhan Tu

Deposit date

2024-04-07

Rights Retention Statement

  • No

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