University of Leicester
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Effect of Acute Walking on Endothelial Function and Postprandial Lipemia in South Asians and White Europeans

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journal contribution
posted on 2023-10-09, 16:27 authored by MJ Roberts, AE Thackray, AJ Wadley, TF Alotaibi, DJ Hunter, J Thompson, K Fujihira, M Miyashita, S Mastana, NC Bishop, E O'donnell, MJ Davies, JA King, T Yates, D Webb, DJ Stensel
Introduction South Asians (SAs) have an elevated risk of cardiovascular disease (CVD) compared with White Europeans (WEs). Postprandial endothelial function (flow-mediated dilatation (FMD%)) in SA women and SA men with central obesity has not been investigated. Research in other populations has highlighted that a 1% higher FMD% is associated with a 13% lower risk of future CVD events. We investigated whether FMD% and lipemia, two markers for CVD risk, were higher in SAs versus WEs, whether walking improved FMD% and lipemia, and if there were ethnic differences in the response. Methods Lean premenopausal women (study 1; 12 SA, 12 WE) and men with central obesity (study 2; 15 SA, 15 WE) completed two 2-d trials. On day 1, participants walked for 60 min at 60% of their peak oxygen uptake or rested. On day 2, participants rested and consumed two high-fat meals over 8 h. Repeated ultrasound assessments of endothelial function and venous blood samples for CVD risk markers were taken. Results Compared with WEs, SAs had lower postprandial FMD% (study 1, -1.32%; study 2, -0.54%) and higher postprandial triacylglycerol concentrations (study 1, 0.31 mmol·L-1·h-1; study 2, 0.55 mmol·L-1·h-1). Walking improved postprandial FMD% (study 1, 1.12%; study 2, 0.94%) and resulted in no significant change or small reductions in postprandial triacylglycerol concentrations (study 1, -0.01 mmol·L-1·h-1; study 2, -0.25 mmol·L-1·h-1). Exercise-induced changes in FMD% and triacylglycerol were consistent between ethnic groups. Conclusions Walking mitigated the adverse postprandial effect of a high-fat diet on FMD% to a similar extent in SA and WE women and men, even with no/small improvements in triacylglycerol. This study highlights the importance of exercise to clinically improve FMD% in SAs and WEs.


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Diabetes Research Centre, University of Leicester


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Medicine and Science in Sports and Exercise






794 - 802


Ovid Technologies (Wolters Kluwer Health)





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United States