University of Leicester
Browse
ORIGIN 2017 DRCP R1 clean.pdf (378.98 kB)

Effect of insulin glargine on recreational physical activity and TV viewing: Analysis of the randomised ORIGIN trial.

Download (378.98 kB)
journal contribution
posted on 2018-01-26, 17:53 authored by Tom Yates, Melanie J. Davies, Hyejung Jung, Jackie Bosch, Giatgen A. Spinas, Seamus Sreenan, Patrick Commerford, Hertzel C. Gerstein, ORGIN investigators
AIMS: To quantify whether insulin therapy, and concomitant weight gain, affects recreational physical activity and TV viewing time using data from the Outcomes Reduction with an Initial Glargine Intervention (ORIGIN) trial. METHODS: 12,537 insulin-naïve individuals with dysglycaemia were randomised to receive either basal insulin glargine or standard care and followed for a median of 6.2years. Complete recreational physical activity and TV viewing time questionnaires across baseline, 2year follow-up and study end were available for 8954 participants. Differences between groups at follow-up were assessed by analysis of covariance. RESULTS: At follow-up, there was no difference in physical activity or TV viewing time between those taking insulin glargine and those receiving standard care, despite body weight increasing by 1.66 (7.56) kg in the insulin glargine group and reducing by -0.65 (7.90) kg in the standard care group (P<0.001). The dose of insulin glargine was not associated with changes in physical activity. CONCLUSIONS: Despite modest weight gain, insulin glargine did not adversely impact recreational physical activity levels within an international cohort with dysglyaemia. ORIGIN ClinicalTrials.gov number: NCT00069784.

Funding

The ORIGIN trial was funded by Sanofi. The funders had no role in the analysis or interpretation of the data presented in this manuscript.

History

Citation

Diabetes Research and Clinical Practice, 2017, 132, pp. 137-143

Author affiliation

/Organisation/COLLEGE OF LIFE SCIENCES/School of Medicine/Diabetes Research Centre

Version

  • AM (Accepted Manuscript)

Published in

Diabetes Research and Clinical Practice

Publisher

Elsevier for International Diabetes Federation

issn

0168-8227

eissn

1872-8227

Acceptance date

2017-07-26

Copyright date

2017

Available date

2018-07-31

Publisher version

https://www.sciencedirect.com/science/article/pii/S0168822717305685?via=ihub

Notes

The file associated with this record is under embargo until 12 months after publication, in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.

Language

en

Usage metrics

    University of Leicester Publications

    Categories

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC