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Effects of an Electronic Software "Prompt" With Health Care Professional Training on Cardiovascular and Renal Complications in a Multiethnic Population With Type 2 Diabetes and Microalbuminuria (the GP-Prompt Study): Results of a Pragmatic Cluster-Randomized Trial.

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Version 2 2020-06-02, 10:17
Version 1 2020-06-02, 10:15
journal contribution
posted on 2020-06-02, 10:17 authored by Andrew Willis, Winston Crasto, Laura J Gray, Helen Dallosso, Ghazala Waheed, Melanie Davies, Sam Seidu, Kamlesh Khunti
OBJECTIVE:Tight, targeted control of modifiable cardiovascular risk factors can reduce cardiovascular complications and mortality in individuals with type 2 diabetes (T2DM) and microalbuminuria. The effects of using an electronic "Prompt" with a treatment algorithm to support a treat-to-target approach has not been tested in primary care. RESEARCH DESIGN AND METHODS:A multicenter, cluster-randomized trial was conducted among primary care practices across Leicestershire, U.K. The primary outcome was the proportion of individuals achieving systolic and diastolic blood pressure (<130 and <80 mmHg, respectively) and total cholesterol (<3.5 mmol/L) targets at 24 months. Secondary outcomes included proportion of individuals with HbA1c <58 mmol/mol (<7.5%), changes in prescribing, change in the albumin-to-creatinine ratio, major adverse cardiovascular events, cardiovascular mortality, and coding accuracy. RESULTS:A total of 2,721 individuals from 22 practices, mean age 63 years, 41% female, and 62% from black and minority ethnic groups completed 2 years of follow-up. There were no significant differences in the proportion of individuals achieving the composite primary outcome, although the proportion of individuals achieving the prespecified outcome of total cholesterol <4.0 mmol (odds ratio 1.24; 95% CI 1.05-1.47; P = 0.01) increased with intensive intervention compared with control. Coding for microalbuminuria increased relative to control (odds ratio 2.05; 95% CI 1.29-3.25; P < 0.01). CONCLUSIONS:Greater improvements in composite cardiovascular risk factor control with this intervention compared with standard care were not achieved in this cohort of high-risk individuals with T2DM. However, improvements in lipid profile and coding can benefit patients with diabetes to alter the high risk of atherosclerotic cardiovascular events. Future studies should consider comprehensive strategies, including patient education and health care professional engagement, in the management of T2DM.

Funding

The work was funded by the Collaboration for leadership in Applied Health Research and Care (CLAHRC) East Midlands, Health Education East Midlands (HEEM) and East Midlands Academic Health Sciences Network (AHSN EM).

History

Citation

Diabetes Care 2020 May; dc192243.

Version

  • AM (Accepted Manuscript)

Published in

Diabetes care

Pagination

dc192243 - dc192243

Publisher

American Diabetes Association

issn

0149-5992

eissn

1935-5548

Acceptance date

2020-04-07

Copyright date

2020

Language

eng

Publisher version

https://care.diabetesjournals.org/content/early/2020/05/19/dc19-2243.abstract

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