Elevation of tumour marker CA-125 in serum & body fluids: interpret with caution

First paragraph: The cancer antigen (CA) -125 is a high molecular mass glycoprotein produced both by ovarian cancer cells as also by normal cells of tissues derived from coelomic epithelium. Serum CA-125 levels are used as a marker of tumour activity in patients known to have ovarian carcinoma1 and commercial tests for serum CA-125 have been available since 1983. In women with histologically proven ovarian carcinoma, levels of serum CA-125 are elevated >35 U/ml in more than 80 per cent of cases. Levels are also measured after debulking surgery and during chemotherapy.