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Enantioselective copper catalysed, direct functionalisation of allenes via allyl copper intermediates
journal contributionposted on 2019-09-18, 14:32 authored by Alexander P. Pulis, Kay Yeung, David J. Procter
The direct functionalisation of allenes under copper catalysis enables efficient access to enantioenriched, densely functionalised molecules. In this review we explore the breadth and depth of a versatile reaction manifold, which involves the element-cupration of allenes to generate allyl copper intermediates that are subsequently coupled with diverse arrays of electrophiles.
We thank the University of Manchester (President's Scholarship to K. Y. and Lectureship to A. P. P.), the SCI (Scholarship to K. Y.), and the EPSRC (Studentships to K. Y. and Established Career Fellowship to D. J. P.). All publication charges for this article have been paid for by the Royal Society of Chemistry
CitationChemical Science, 2017, 8 (8), pp. 5240-5247
Author affiliation/Organisation/COLLEGE OF SCIENCE AND ENGINEERING/Department of Chemistry
- VoR (Version of Record)