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Essential medicines containing ethanol elevate blood acetaldehyde concentrations in neonates

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posted on 2016-08-23, 12:03 authored by H. C. Pandya, H. Mulla, M. Hubbard, R. L. Cordell, Paul S. Monks, S. Yakkundi, J. C. McElnay, A. J. Nunn, M. A. Turner, ESNEE consortium
Neonates administered ethanol-containing medicines are potentially at risk of dose-dependent injury through exposure to ethanol and its metabolite, acetaldehyde. Here, we determine blood ethanol and acetaldehyde concentrations in 49 preterm infants (median birth weight = 1190 g) dosed with iron or furosemide, medicines that contain different amounts of ethanol, and in 11 control group infants (median birth weight = 1920 g) who were not on any medications. Median ethanol concentrations in neonates administered iron or furosemide were 0.33 (range = 0–4.92) mg/L, 0.39 (range = 0–72.77) mg/L and in control group infants were 0.15 (range = 0.03–5.4) mg/L. Median acetaldehyde concentrations in neonates administered iron or furosemide were 0.16 (range = 0–8.89) mg/L, 0.21 (range = 0–2.43) mg/L and in control group infants were 0.01 (range = 0–0.14) mg/L. There was no discernible relationship between blood ethanol or acetaldehyde concentrations and time after medication dose. Conclusion: Although infants dosed with iron or furosemide had low blood ethanol concentrations, blood acetaldehyde concentrations were consistent with moderate alcohol exposure. The data suggest the need to account for the effects of acetaldehyde in the benefit-risk analysis of administering ethanol-containing medicines to neonates.

History

Citation

European Journal of Pediatrics , 2016, 175 (6), pp. 841-847

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Infection, Immunity and Inflammation

Version

  • VoR (Version of Record)

Published in

European Journal of Pediatrics

Publisher

Springer Verlag

issn

0340-6199

eissn

1432-1076

Copyright date

2016

Available date

2016-08-23

Publisher version

http://link.springer.com/article/10.1007/s00431-016-2714-x

Language

en

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