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Ethnic differences in cardiac structure and function assessed by MRI in healthy South Asian and White European people: A UK Biobank Study

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posted on 2024-05-13, 15:59 authored by Kelly S Parke, Emer M Brady, Aseel Alfuhied, Rishabh S Motiwale, Cameron RaziehCameron Razieh, Anvesha Singh, Jayanth R Arnold, Matthew PM Graham-Brown, Joanna M Bilak, Sarah L Ayton, Abhishek Dattani, Jian L Yeo, Gerry P McCann, Gaurav S Gulsin

Echocardiographic studies indicate South Asian people have smaller ventricular volumes, lower mass and more concentric remodelling than White European people, but there are no data using cardiac MRI (CMR). We aimed to compare CMR quantified cardiac structure and function in White European and South Asian people.Healthy White European and South Asian participants in the UK Biobank Imaging CMR sub-study were identified by excluding those with a history of cardiovascular disease, hypertension, obesity or diabetes. Ethnic groups were matched by age and sex. Cardiac volumes, mass and feature tracking strain were compared.121 matched pairs (77 male/44 female, mean age 58 ± 8 years) of South Asian and White European participants were included. South Asian males and females had smaller absolute but not indexed left ventricular (LV) volumes, and smaller absolute and indexed right ventricular volumes, with lower absolute and indexed LV mass and lower LV mass:volume than White European participants. Although there were no differences in ventricular or atrial ejection fractions, LV global longitudinal strain was higher in South Asian females than White European females but not males, and global circumferential strain was higher in both male and South Asian females than White European females. Peak early diastolic strain rates were higher in South Asian versus White European males, but not different between South Asian and White European females.Contrary to echocardiographic studies, South Asian participants in the UK Biobank study had less concentric remodelling and higher global circumferential strain than White European subjects. These findings emphasise the importance of sex- and ethnic- specific normal ranges for cardiac volumes and function.

Background

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Funding

Heart failure in type 2 diabetes: improving diagnosis and management in a multi-ethnic population.

NIHR Academy

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Leicester NIHR Biomedical Research Centre and Clinical Research Facility

Research Fellowship Award from the British Society for Heart Failure

A novel cardiac magnetic resonance technique to quantify altered myocardial calcium handling in diabetic cardiomyopathy and the response to lifestyle intervention (Dr Abhishek Dattani)

British Heart Foundation

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History

Author affiliation

College of Life Sciences/Population Health Sciences

Version

  • VoR (Version of Record)

Published in

Journal of Cardiovascular Magnetic Resonance

Volume

26

Issue

1

Pagination

100001

Publisher

Elsevier BV

issn

1097-6647

eissn

1532-429X

Copyright date

2024

Available date

2024-05-13

Spatial coverage

England

Language

en

Deposited by

Dr Anvesha Singh

Deposit date

2024-05-09

Data Access Statement

The imaging datasets analysed for the current study are available in the UK Biobank repository. The resulting quantitative imaging data generated during the current study are available from the corresponding author on reasonable request.

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