Exercise-induced Biochemical Modifications in Muscle in Chronic Kidney Disease: Occult Acidosis as a Potential Factor Limiting the Anabolic Effect of Exercise

There is growing evidence that exercise may be beneficial in limiting or reversing problems related to chronic kidney disease (CKD); but exercise therapy has had limited success in increasing lean body mass, implying that metabolic abnormalities in muscle during CKD may limit the anabolic effectiveness of exercise. This short review summarizes evidence that exercise may result in a transient worsening of the pre-existing metabolic acidosis that occurs in these patients; a metabolic defect that may reverse the normal anabolic effects of exercise.