University of Leicester
Browse
EIR manuscript - post reviewers.docx (464.69 kB)

Exercise, inflammation and acute cardiovascular events

Download (464.69 kB)
journal contribution
posted on 2022-08-03, 16:27 authored by S Pallikadavath, GM Walters, TA Kite, M Graham-Brown, A Ladwiniec, M Papadakis, GP McCann, A Singh

Individuals who participate in regular exercise over time have a markedly reduced risk of cardiovascular disease. Paradoxically, in susceptible individuals with underlying, often undiagnosed, disease states, exercise may acutely increase an individual's risk of cardiovascular events during and immediately following physical exertion. Exercise is thought to evoke conditions that trigger atheromatous plaque rupture or trigger life threatening arrhythmias in individuals with pre-existing, vulnerable coronary artery and inherited cardiovascular disease respectively. This transient increased risk may be driven by the inflammatory trigger provided by physical exertion where exercise is associated with an upregulation of inflammatory mediators in the acute phase. Conversely, habitual exercise can lead to a modulation of the inflammatory response over time. This review explores: exercise related inflammation; acute cardiovascular events related to exercise and strategies to mitigate these risks.

History

Author affiliation

Department of Cardiovascular Sciences, University of Leicester

Version

  • AM (Accepted Manuscript)

Published in

Exercise immunology review

Volume

28

Pagination

93 - 103

Publisher

The International Society of Exercise Immunology

issn

1077-5552

Copyright date

2022

Available date

2023-11-16

Spatial coverage

Germany

Language

eng

Usage metrics

    University of Leicester Publications

    Categories

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC