University of Leicester
Browse
1471-2164-8-392.pdf (820.36 kB)

Exonization of active mouse LIs: a driver of transcriptome evolution?

Download (820.36 kB)
journal contribution
posted on 2008-02-11, 12:50 authored by Tomasz Zemojtel, Tobias Penzkofe, Jorg Schultz, Thomas Dandekar, Richard M. Badge, Martin Vingron
Background:Long interspersed nuclear elements (LINE-1s, L1s) have been recently implicated in the regulation of mammalian transcriptomes. Results:Here, we show that members of the three active mouse L1 subfamilies (A, G[subscript F] and T[subscript F]) contain, in addition to those on their sense strands, conserved functional splice sites on their antisense strands, which trigger multiple exonization events. The latter is particularly intriguing in the light of the strong antisense orientation bias of intronic L1s, implying that the toleration of antisense insertions results in an increased potential for exonization. Conclusion:In a genome-wide analysis, we have uncovered evidence suggesting that the mobility of the large number of retrotransposition-competent mouse L1s (~2400 potentially active L1s in NCBIm35) has significant potential to shape the mouse transcriptome by continuously generating insertions into transcriptional units.

History

Citation

BMC Genomics, 2007, 8:392

Version

  • VoR (Version of Record)

Published in

BMC Genomics

Publisher

BioMed Central Ltd

eissn

1471-2164

Copyright date

2007

Available date

2008-02-11

Publisher version

http://www.biomedcentral.com/1471-2164/8/392

Language

de

Usage metrics

    University of Leicester Publications

    Categories

    Keywords

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC