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Feasibility and acceptability of continuous glucose monitoring in pregnancy for the diagnosis of gestational diabetes: A single-centre prospective mixed methods study

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posted on 2024-07-04, 13:21 authored by Laura C Kusinski, Joanne Brown, Deborah J Hughes, Claire L Meek
Background Undiagnosed diabetes in pregnancy is associated with stillbirth and perinatal complications, but standard testing for gestational diabetes using the oral glucose tolerance test (OGTT) is impractical and exacerbates healthcare inequalities. There is an urgent need to improve the accuracy, acceptability and accessibility of glucose testing in pregnancy. We qualitatively assessed the feasibility and acceptability of two alternative home-based methods of glucose testing in pregnant women, using continuous glucose monitoring (CGM), with or without a home-based OGTT. Methods We recruited women with a singleton pregnancy at 28 weeks’ gestation with ≥1 risk factor for gestational diabetes attending antenatal glucose testing. A Dexcom G6 CGM device was sited and women were asked to take a 75g OGTT solution (Rapilose) on day 4 after an overnight fast. Qualitative interviews were performed with 20 participants using video conferencing according to a semi-structured interview schedule and thematically analysed using NVIVO software. Results 92 women were recruited; 73 also underwent a home OGTT. Women had an average of 6.9 days of glucose monitoring and found the CGM painless, easy to use with few or no adverse events. During the qualitative study, the main themes identified were reassurance and convenience. All women interviewed would recommend CGM and a home OGTT for diagnosis of gestational diabetes. Conclusions CGM with or without a home OGTT is feasible and acceptable to pregnant women for diagnosis of gestational diabetes and offered advantages of convenience and reassurance. Further work is needed to clarify diagnostic thresholds for gestational diabetes using CGM metrics.

History

Citation

PLoS ONE 18(9): e0292094

Author affiliation

College of Life Sciences Population Health Sciences

Version

  • VoR (Version of Record)

Published in

PLOS ONE

Volume

18

Issue

9

Publisher

Public Library of Science (PLoS)

issn

1932-6203

eissn

1932-6203

Acceptance date

2023-03-20

Copyright date

2023

Available date

2024-07-04

Editors

Hoddinott G

Spatial coverage

United States

Language

en

Deposited by

Professor Claire Meek

Deposit date

2024-07-03

Data Access Statement

All relevant data are within the manuscript and its Supporting Information files.

Rights Retention Statement

  • No

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