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Five serum fatty acids are associated with subclinical hypothyroidism in a Chinese pregnant population.

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posted on 2020-04-30, 08:40 authored by Ting Zhang, Yinyin Xia, Ting-Li Han, Hua Zhang, Philip N Baker
Subclinical hypothyroidism (SCH) is a common endocrine disorder affecting women of reproductive age. Although SCH and abnormal fatty acid composition are often associated with adverse pregnancy outcomes and metabolic syndrome later in maternal and fetal life, the longitudinal relationship between SCH and serum fatty acids during pregnancy has rarely been studied. Therefore, the aim of this study was to investigate the association between SCH and maternal serum fatty acids throughout gestation. A total of 240 women enrolled in the Complex Lipids in Mothers and Babies (CLIMB) study in Chongqing, China were included in our study. Clinical information and maternal serum samples were collected at three time points during pregnancy: 11-14th, 22-28th, and 32-34th weeks of gestation. Twenty serum fatty acids were quantified using gas chromatography-mass spectrometry (GC-MS) analysis. A majority of the 20 serum fatty acids increased as gestation progressed in women with a normal pregnancy and women experiencing SCH. Levels of arachidic acid, docosahexaenoic acid, and eicosenoic acid were significantly higher in the serum of women with SCH when compared to women with a normal pregnancy, in the second trimester. On the other hand, the levels of eicosadienoic acid and octadecanoic acid were significantly higher in SCH in the third trimester. Our findings demonstrate that serum fatty acid composition during the second and third trimesters was significantly associated with SCH in pregnant Chinese women.

Funding

The authors are grateful to the women who participated in this study and the health-care staff who were involved in data and sample collection at the First Affiliated Hospital of Chongqing Medical University and the Chongqing Health Center for Women and Children. This work was supported by the National Natural Science Foundation of China (No.81571453, 81771607, 81871185, 81701477, 81961128004), The 111 Project (Yuwaizhuan (2016)32), The National Key Research and Development Program of Reproductive Health & Major Birth Defects Control and Prevention (2016YFC1000407), Chongqing Health Commission (2017ZDXM008, 2018ZDXM024), and Chongqing Science & Technology Commission (cstc2017jcyjBX0062). This study was also supported by the New Zealand Primary Growth Partnership post farm gate dairy programme, funded by Fonterra Co-operative Group Ltd, New Zealand and the New Zealand Ministry for Primary Industries.

History

Citation

Zhang, T., Xia, Y., Han, T. et al. Five serum fatty acids are associated with subclinical hypothyroidism in a Chinese pregnant population. Sci Rep 10, 6743 (2020). https://doi.org/10.1038/s41598-020-63513-7

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  • VoR (Version of Record)

Published in

Scientific reports

Volume

10

Issue

1

Pagination

6743

Publisher

Springer Science and Business Media LLC

issn

2045-2322

eissn

2045-2322

Acceptance date

2020-03-23

Copyright date

2020

Available date

2020-04-21

Publisher version

https://www.nature.com/articles/s41598-020-63513-7

Spatial coverage

China

Language

eng

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