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florid-endocervical-microglandular-hyperplasia-in-association-with-tamoxifentreatment-2157-7099-1000375.pdf (885.36 kB)

Florid Endocervical Microglandular Hyperplasia in Association with Tamoxifen Treatment

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posted on 2016-04-08, 09:03 authored by T. Ayakannu, W. S. R. Hew, L. Brown, S. Ismail, T. G. Maulik, S. W. Kiberu, Anthony H. Taylor
Background: Although tamoxifen has well documented oestrogen-like effects in the endometrium and ectocervical squamous epithelium, its effects on the endocervix are poorly documented. Case report: We report a case of an 88 year-old woman who presented with postmenopausal bleeding after receiving tamoxifen for 16 months following a diagnosis of Grade 2 invasive and in situ carcinoma of breast. Endometrial biopsy was performed revealing either atypical hyperplasia or adenocarcinoma. She underwent total abdominal hysterectomy, bilateral salpingo-oophorectomy and lymph gland sampling. Histopathological examination of the uterus showed an endometrioid carcinoma (FIGO Grade 2) at the endometrium. In addition, there was extensive florid endocervical microglandular hyperplasia. Conclusion: Endocervical microglandular hyperplasia is usually seen in woman of reproductive age, particularly in association with pregnancy and contraceptive use. It is unusual in postmenopausal woman and its presence in this 88 year-old tamoxifentreated patient implicates tamoxifen as a course of endocervical microglandular hyperplasia in this instance.

History

Citation

Journal of Cytology and Histology, 2015, 6 (6), 375

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Medical Education

Version

  • VoR (Version of Record)

Published in

Journal of Cytology and Histology

Publisher

OMICS International

eissn

2157-7099

Acceptance date

2015-10-13

Copyright date

2015

Available date

2016-04-08

Publisher version

http://www.omicsonline.org/open-access/florid-endocervical-microglandular-hyperplasia-in-association-with-tamoxifentreatment-2157-7099-1000375.php?aid=62836

Language

en

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