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From GWAS to new biology and treatments in CAD.pdf (271.23 kB)

From GWAS to new biology and treatments in CAD.

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journal contribution
posted on 2019-06-13, 11:05 authored by Peter D. Jones, Tom R. Webb
Coronary artery disease (CAD), which remains a leading cause of mortality worldwide [1], is caused by the development of atherosclerotic plaques in the arterial wall. Disease risk is influenced by environmental and lifestyle factors as well as having a significant genetic component. Over the last decade, genome-wide association studies (GWAS) have revealed the chromosomal loci contributing to increased CAD susceptibility, with the most recent investigation linking more than 300 genetic variants to disease [2]. A key characteristic of these loci is that most do not work through traditional CAD risk factors and current treatment targets such as plasma LDL-cholesterol levels or blood pressure. Importantly, for the majority of loci the underlying mechanism is unknown suggesting that our knowledge of disease pathogenesis is far from complete. CAD loci therefore offer a resource for the understanding of the molecular pathways and biological processes driving disease and potential identification of therapeutic targets.

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Citation

Aging, 2019, 11 (6), pp. 1611-1612

Author affiliation

/Organisation/COLLEGE OF LIFE SCIENCES/School of Medicine/Department of Cardiovascular Sciences

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  • VoR (Version of Record)

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Aging

Publisher

Impact Journals

eissn

1945-4589

Acceptance date

2019-03-21

Copyright date

2019

Available date

2019-06-13

Publisher version

https://www.aging-us.com/article/101891/text

Language

en

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