Fungal sensitization and its relationship to mepolizumab response in patients with severe eosinophilic asthma

Letter to the Editor: In asthma, sensitization to fungal, perennial or seasonal allergens increases the risk of uncontrolled symptoms, exacerbations and poor disease outcomes.1 In severe asthma, typically 20%-29% of patients show sensitization to ≥1 fungal allergen, with Aspergillus being one of the most common.2-4 These patients have worse lung function, increased risk of oral corticosteroid use, hospitalization and a greater degree of airflow obstruction than patients non-sensitized to fungal allergens. [opening paragraph]