University of Leicester
GWAS Central: a comprehensive resource for the comparison and interrogation of genome-wide association studies..pdf (929.75 kB)

GWAS Central: a comprehensive resource for the comparison and interrogation of genome-wide association studies

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journal contribution
posted on 2016-04-12, 12:00 authored by T. Beck, R. K. Hastings, S. Gollapudi, R. C. Free, Anthony Joseph Brookes
To facilitate broad and convenient integrative visualization of and access to GWAS data, we have created the GWAS Central resource ( This database seeks to provide a comprehensive collection of summary-level genetic association data, structured both for maximal utility and for safe open access (i.e., non-directional signals to fully preclude research subject identification). The resource emphasizes on advanced tools that allow comparison and discovery of relevant data sets from the perspective of genes, genome regions, phenotypes or traits. Tested markers and relevant genomic features can be visually interrogated across up to 16 multiple association data sets in a single view, starting at a chromosome-wide view and increasing in resolution down to individual bases. In addition, users can privately upload and view their own data as temporary files. Search and display utility is further enhanced by exploiting phenotype ontology annotations to allow genetic variants associated with phenotypes and traits of interest to be precisely identified, across all studies. Data submissions are accepted from individual researchers, groups and consortia, whereas we also actively gather data sets from various public sources. As a result, the resource now provides over 67 million P-values for over 1600 studies, making it the world's largest openly accessible online collection of summary-level GWAS association information.



European Journal of Human Genetics, 2014, 22 (7), pp. 949-952

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/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/MBSP Non-Medical Departments/Department of Genetics


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European Journal of Human Genetics


Nature Publishing Group for European Society of Human Genetics





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