posted on 2020-06-09, 10:30authored byChiara Batini, Tineka Blake, A. Mesut Erzurumluoglu, Peter S. Braund, Christopher P. Nelson, Nilesh J. Samani, Nick Shrine, Martin D. Tobin, Louise V. Wain, et al.
High blood pressure is a highly heritable and modifiable risk factor for cardiovascular
disease. We report the largest genetic association study of blood pressure traits (systolic,
diastolic, pulse pressure) to date in over one million people of European ancestry. We
identify 535 novel blood pressure loci that not only offer new biological insights into blood
pressure regulation but also reveal shared genetic architecture between blood pressure and
lifestyle exposures. Our findings identify new biological pathways for blood pressure
regulation with potential for improved cardiovascular disease prevention in the future.
H.R.W. was funded by the National Institute for Health Research (NIHR) as part of the
portfolio of translational research of the NIHR Biomedical Research Centre at Barts and The
London School of Medicine and Dentistry. D.M-A is supported by the Medical Research
Council [grant number MR/L01632X.1]. B.M. holds an MRC eMedLab Medical Bioinformatics
Career Development Fellowship, funded from award MR/L016311/1. H.G. was funded by
the NIHR Imperial College Health Care NHS Trust and Imperial College London Biomedical
Research Centre. C.P.C. was funded by the National Institute for Health Research (NIHR) as
part of the portfolio of translational research of the NIHR Biomedical Research Center at
Barts and The London School of Medicine and Dentistry. S.T. was supported by Canadian
Institutes of Health Research; Université Laval (Quebec City, Canada). G.P. was supported by
Canada Research Chair in Genetic and Molecular Epidemiology and CISCO Professorship in
Integrated Health Biosystems. I.K. was supported by the EU PhenoMeNal project (Horizon
2020, 654241). C.P.K. is supported by grant U01DK102163 from the NIH-NIDDK, and by
resources from the Memphis VA Medical Center. C.P.K. is an employee of the US
Department of Veterans affairs. Opinions expressed in this paper are those of the authors’
and do not necessarily represent the opinion of the Department of Veterans Affairs. S.D.
was supported for this work by grants from the European Research Council (ERC), the EU
Joint Programme - Neurodegenerative Disease Research (JPND), the Agence Nationale de la
Recherche (ANR). T.B., J.MART., V.V., A.F.W. and C.H. were supported by a core MRC grant
to the MRCHGU QTL in Health and Disease research programme. M.BOE is supported by NIH
grant R01-DK062370. H.W. and A.G. acknowledge support of the Tripartite
Immunometabolism Consortium [TrIC], Novo Nordisk Foundation (grant NNF15CC0018486).
N.V. was supported by Marie Sklodowska-Curie GF grant (661395) and ICIN-NHI. C.M
Nature Genetics, 2018, 50, pp. 1412–1425
/Organisation/COLLEGE OF LIFE SCIENCES/School of Medicine/Department of Health Sciences
In the version of this article originally published, the name of author Martin H. de Borst was coded incorrectly in the XML. The error has now been corrected in the HTML version of the paper on version of record.