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Genetic determinants of telomere length and cancer risk

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journal contribution
posted on 2020-04-07, 16:01 authored by CP Nelson, V Codd
The relationship of telomere length with cancer risk has been the source of much debate within epidemiological studies, which have produced inconsistent finding both between and within different cancer types. Over recent years, genome-wide association studies of increasing size have identified variants that determine human telomere length. These variants have subsequently been utilised as instrumental variables in Mendelian randomisation based studies, allowing the investigation of potential causal relationships between telomere length and cancer. Here we discuss recent advances in both genomic discovery, studies that give increasing evidence towards a causal role for telomere length in cancer risk and considerations for future studies.

History

Citation

Current Opinion in Genetics and Development 2020, 60:63–68

Published in

Current Opinion in Genetics and Development

Volume

60

Pagination

63 - 68

Publisher

Elsevier BV

issn

0959-437X

eissn

1879-0380

Acceptance date

2020-02-03

Copyright date

2020

Available date

2020-03-11

Publisher version

https://www.sciencedirect.com/science/article/pii/S0959437X20300125

Language

eng

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