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Gut-related metabolites are associated with respiratory symptoms in COVID-19: a proof-of-concept study

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posted on 2022-01-18, 14:48 authored by Muhammad Zubair Israr, Wadah Ibrahim, Andrea Salzano, Sarir Sarmad, Michael J Wilde, Rebecca L Cordell, Neil J Greening, Christopher E Brightling, Salman Siddiqui, Toru Suzuki, EMBER consortium
Gut-related metabolites have been linked with respiratory disease. The crosstalk between the gut and lung suggests that gut health may be compromised in COVID-19. The aims of the present study were to analyse a panel of gut-related metabolites (acetyl-L-carnitine, betaine, choline, L-carnitine, trimethylamine and TMAO) in COVID-19 patients, matched with healthy subjects, and non-COVID-19 respiratory patients. As results, metabolites from this panel are impaired in COVID-19, associated with symptoms (breathlessness and temperature) and able to differentiate between COVID-19 and asthma. Preliminary results show lower levels of betaine appear to be associated with poor outcomes in COVID-19 patients suggesting betaine as a marker of gut microbiome health.

History

Citation

Nutrition, 2022, https://doi.org/10.1016/j.nut.2021.111585

Author affiliation

Department of Cardiovascular Sciences, University of Leicester

Version

  • AM (Accepted Manuscript)

Published in

Nutrition

Pagination

111585 - 111585

Publisher

Elsevier BV

issn

0899-9007

Acceptance date

2021-12-27

Copyright date

2022

Available date

2023-01-05

Language

en

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