University of Leicester
Browse
1-s2.0-S0887899419302243-main.pdf (1.22 MB)

Hand preference develops across childhood and adolescence in extremely preterm children: The EPICure Study

Download (1.22 MB)
Version 2 2020-04-21, 15:31
Version 1 2020-04-21, 14:58
journal contribution
posted on 2020-04-21, 15:31 authored by N Marlow, B Joanne, H O'Reilly, S Johnson, D Wolke, J Morris

Aim

We attempted to determine how handedness changes with age and its relation to brain injury and cognition following birth before 26 weeks of gestation.

Methods

We used data from the EPICure study of health and development following birth in the British Isles in 1995. Handedness was determined by direct observation during standardized testing at age 2.5, six, and 11 years and by self-report using the Edinburgh Handedness Inventory at 19 years. Control data from term births were included at six, 11, and 19 years.

Results

In extremely preterm children left handedness increased from 9% to 27% between 2.5 and 19 years, with a progressive reduction in mixed handedness from 59% to 13%. Although individual handedness scores varied over childhood, the between-group effects were consistent through 19 years, with greatest differences in females. In extremely preterm participants, neonatal brain injury was associated with lower right handedness scores at each age and left-handed participants had lower cognitive scores at 19 years after controlling for confounders, but not at other ages.

Conclusion

Increasing hand lateralization is seen over childhood in extremely preterm survivors, but consistently more individuals have non-right preferences at each age than control individuals.

Funding

This study was funded by the Medical Research Council UK (Ref 72524). N.M. receives a proportion of funding from the Department of Health's NIHR Biomedical Research Centre's funding scheme at UCLH/UCL.

History

Citation

Pediatric Neurology Volume 99, October 2019, Pages 40-46

Author affiliation

/Organisation/COLLEGE OF LIFE SCIENCES/School of Medicine/Department of Health Sciences

Version

  • VoR (Version of Record)

Published in

Pediatric Neurology

Volume

99

Pagination

40-46

Publisher

Elsevier

issn

1873-5150

Acceptance date

2019-04-14

Copyright date

2019

Available date

2019-04-19

Publisher version

https://www.sciencedirect.com/science/article/pii/S0887899419302243

Language

en

Usage metrics

    University of Leicester Publications

    Categories

    No categories selected

    Licence

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC