Haplotype estimation for biobank scale datasets
journal contributionposted on 2016-06-16, 13:19 authored by Jared O’Connell, Kevin Sharp, Nick Shrine, Louise Wain, Ian Hall, Martin Tobin, Jean-Francois Zagury, Olivier Delaneau, Jonathan Marchini
The UK Biobank (UKB) has recently released genotypes on 152,328 individuals together with extensive phenotypic and lifestyle information. We present a new phasing method SHAPEIT3 that can handle such biobank scale datasets and results in switch error rates as low as ~0.3%. The method exhibits O(NlogN) scaling in sample size (N), enabling fast and accurate phasing of even larger cohorts.
CitationNature Genetics, 2016, 48, pp. 817–820
Author affiliation/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Health Sciences
- AM (Accepted Manuscript)