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Moss Clin Onc 2016.pdf (151.18 kB)

Iatrogenic menopause following radiotherapy treatment

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journal contribution
posted on 2022-08-02, 16:28 authored by E Moss, S Taneja, F Munir, C Kent, L Robinson, N Potdar, P Sarhanis, H McDermott

 The ever-improving prognosis of women diagnosed with cervical cancer has meant that survivorship and treatment-related sequelae are being brought more into the spotlight in an attempt to try to reduce morbidity and improve women's long-term health. However, there are many issues surrounding an iatrogenic menopause in cervical cancer, a variety of potential management options and barriers to treatment. Women who have become menopausal under the age of 45 years as a result of cervical cancer are significantly less likely to start hormone replacement therapy (HRT) or continue it long term as compared with those who have undergone a surgical menopause for a benign reason. High profile media reports raising concerns about the safety of HRT use have left many women reluctant to consider HRT as a therapeutic option for menopausal symptoms and many are seeking to use complementary/alternative medicine, including non-pharmacological interventions, to alleviate symptoms. The benefits of HRT in this population have been shown to reduce these effects, although adherence to treatment regimens is a challenge due to poor compliance, which is in part due to the fear of a second malignancy. The development of non-HRT-based interventions to ameliorate menopausal symptoms and reduce the long-term health consequences are needed for women who choose not to take HRT. 

History

Author affiliation

Department of Cancer Studies, University of Leicester

Version

  • AM (Accepted Manuscript)

Published in

Clinical Oncology

Volume

28

Issue

12

Pagination

766 - 766

Publisher

Elsevier

issn

1433-2981

Acceptance date

2016-06-13

Copyright date

2016

Available date

2022-08-02

Language

en

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