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Identification of G-quadruplexes in long functional RNAs using 7-deazaguanine RNA

journal contribution
posted on 2016-11-14, 16:18 authored by Carika Weldon, Isabelle Behm-Ansmant, Laurence H. Hurley, Glenn A. Burley, Christiane Branlant, Ian C. Eperon, Cyril Dominguez
RNA G-quadruplex (G4) structures are thought to affect biological processes, including translation and pre-mRNA splicing, but it is not possible at present to demonstrate that they form naturally at specific sequences in long functional RNA molecules. We developed a new strategy, footprinting of long 7-deazaguanine-substituted RNAs (FOLDeR), that allows the formation of G4s to be confirmed in long RNAs and under functional conditions.

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Citation

Nature Chemical Biology, 2017, 13, pp. 18-20

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/MBSP Non-Medical Departments/Molecular & Cell Biology

Version

  • AM (Accepted Manuscript)

Published in

Nature Chemical Biology

Publisher

Nature Publishing Group

issn

1552-4450

eissn

1552-4469

Acceptance date

2016-08-31

Copyright date

2016

Available date

2017-05-07

Publisher version

http://www.nature.com/nchembio/journal/vaop/ncurrent/full/nchembio.2228.html

Language

en

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