Identification of G-quadruplexes in long functional RNAs using 7-deazaguanine RNA
journal contributionposted on 2016-11-14, 16:18 authored by Carika Weldon, Isabelle Behm-Ansmant, Laurence H. Hurley, Glenn A. Burley, Christiane Branlant, Ian C. Eperon, Cyril Dominguez
RNA G-quadruplex (G4) structures are thought to affect biological processes, including translation and pre-mRNA splicing, but it is not possible at present to demonstrate that they form naturally at specific sequences in long functional RNA molecules. We developed a new strategy, footprinting of long 7-deazaguanine-substituted RNAs (FOLDeR), that allows the formation of G4s to be confirmed in long RNAs and under functional conditions.
CitationNature Chemical Biology, 2017, 13, pp. 18-20
Author affiliation/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/MBSP Non-Medical Departments/Molecular & Cell Biology
- AM (Accepted Manuscript)