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Impact of Early Consumption of High-Fat Diet on the Mesolimbic Dopaminergic System

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journal contribution
posted on 2020-04-30, 15:11 authored by F Naneix, F Tantot, C Glangetas, J Kaufling, Y Janthakhin, C Boitard, V De Smedt-Peyrusse, JR Pape, S Vancassel, P Trifilieff, F Georges, E Coutureau, G Ferreira
Increasing evidence suggest that consumption of high-fat diet (HFD) can impact the maturation of brain circuits, such as during adolescence, which could account for behavioral alterations associated with obesity. In the present study, we used behavioral sensitization to amphetamine to investigate the effect of periadolescent HFD exposure (pHFD) in rats on the functionality of the dopamine (DA) system, a central actor in food reward processing. pHFD does not affect responding to an acute injection, however, a single exposure to amphetamine is sufficient to induce locomotor sensitization in pHFD rats. This is paralleled by rapid neurobiological adaptations within the DA system. In pHFD-exposed animals, a single amphetamine exposure induces an increase in bursting activity of DA cells in the ventral tegmental area (VTA) as well as higher DA release and greater expression of (tyrosine hydroxylase, TH) in the nucleus accumbens (NAc). Post-synaptically, pHFD animals display an increase in NAc D2 receptors and c-Fos expression after amphetamine injection. These findings highlight the vulnerability of DA system to the consumption of HFD during adolescence that may support deficits in reward-related processes observed in obesity.

Funding

This work was supported by the following grants: Emergence de Jeune Equipe INRA 2010–2012 (to G.F.), ANR-14-CE13-0014 GOAL (to E.C., G.F.) ANR-15-CE17-0013 OBETEEN (to G.F., E.C.), ANR-10-IDEX-03-02 (to P.T.), and NARSAD Young investigator grant from the Brain and Behavior Foundation (to P.T.). F.T. was the recipient of a fellowship from the French Ministry of Research and Higher Education (2012-2015). F.N. was recipient of a postdoctoral fellowship from ANR (2015–2016).

History

Citation

eNeuro, 2017, 4 (3)

Author affiliation

College of Life Sciences

Version

  • VoR (Version of Record)

Published in

eNeuro

Volume

4

Issue

3

Publisher

Society for Neuroscience

eissn

2373-2822

Acceptance date

2017-05-10

Copyright date

2017

Publisher version

https://www.eneuro.org/content/4/3/ENEURO.0120-17.2017

Language

English