Impact on survival of modelling increased surgical resection rates in patients with Non-Small Cell Lung Cancer and cardiovascular comorbidities: a VICORI study
Background
The impact of cardiovascular disease (CVD) comorbidity on resection rates and survival for patients with early-stage non-small-cell lung cancer (NSCLC) is unclear. We explored if CVD comorbidity explained surgical resection rate variation and the impact on survival if resection rates increased.
Methods
Cancer registry data consisted of English patients diagnosed with NSCLC from 2012 to 2016. Linked hospital records identified CVD comorbidities. We investigated resection rate variation by geographical region using funnel plots; resection and death rates using time-to-event analysis. We modelled an increased propensity for resection in regions with the lowest resection rates and estimated survival change.
Results
Among 57,373 patients with Stage 1−3A NSCLC, resection rates varied considerably between regions. Patients with CVD comorbidity had lower resection rates and higher mortality rates. CVD comorbidity explained only 1.9% of the variation in resection rates. For every 100 CVD comorbid patients, increasing resection in regions with the lowest rates from 24 to 44% would result in 16 more patients resected and alive after 1 year and two fewer deaths overall.
Conclusions
Variation in regional resection rate is not explained by CVD comorbidities. Increasing resection in patients with CVD comorbidity to the levels of the highest resecting region would increase 1-year survival.
Funding
The study was funded by a joint research grant from the British Heart foundation 405 (SP/16/5/32415) and Cancer Research UK (C53325/A21134).
History
Citation
British Journal of Cancer, volume 123, pages 471–479 (2020)Author affiliation
College of Life SciencesVersion
- VoR (Version of Record)