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Gomis R et al DRCP primary manuscript resubmission v1.pdf (207.1 kB)

Improving metabolic control in sub-optimally controlled subjects

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posted on 2007-08-20, 08:58 authored by R. Gomis, F. Storms, I. Conget, P. Sinnassamy, Melanie J. Davies
This study assessed the incidence of severe hypoglycaemia with two insulin glargine titration algorithms: Algorithm 1 (increments of at least 10%, but not exceeding 4 U) versus Algorithm 2 (1–6 U increments). In this multicenter (n=409), multinational (n=54), open-label, 24-week randomized trial in 2442 subjects with sub-optimally controlled Type 1 diabetes (T1DM), mean prior insulin therapy duration was 14.6±10.3 years. The incidence of severe hypoglycaemia was similar with Algorithms 1 and 2 (16.6 vs 14.4 events per 100 patient–years). There were similar rates of both symptomatic and nocturnal hypoglycaemia. HbA1c and fasting blood glucose (FBG) decreased significantly (baseline to endpoint; p<0.001), and comparably with Algorithms 1 and 2 (HbA1c: –0.64 vs –0.72%; FBG: –57 vs –59 mg/dL). Mean basal insulin dose increased with both algorithms (+5.7 vs +5.9 U). In a diverse population with longstanding T1DM, transfer from any insulin regimen, including basal–bolus or premixed insulin to an insulin glargine-based regimen resulted in significant improvements in glycaemic control, with low rates of severe hypoglycaemia, irrespective of the titration algorithm used.

History

Citation

DIABETES RESEARCH AND CLINICAL PRACTICE, 2007, 77 (1), pp.84-91

Published in

DIABETES RESEARCH AND CLINICAL PRACTICE

Publisher

Elsevier

Available date

2007-08-20

Notes

This is the author's final draft of an article published in Diabetes Research & Clinical Practice http://www.elsevier.com/wps/find/journaldescription.cws_home/505949/description#description

Language

en

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