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Indole-containing arene-ruthenium complexes with broad spectrum activity against antibiotic-resistant bacteria

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posted on 2024-04-23, 08:23 authored by Victoria C Nolan, Laia Rafols, James Harrison, Joan J Soldevila-Barreda, Marialuisa Crosatti, Natalie GartonNatalie Garton, Malgorzata Wegrzyn, Danielle L Timms, Colin C Seaton, Helen Sendron, Maria Azmanova, Nicolas PE Barry, Anaïs Pitto-Barry, Jonathan AG Cox
Antimicrobial resistant (AMR) bacteria are emerging and spreading globally, threatening our ability to treat common infectious diseases. The development of new classes of antibiotics able to kill or inhibit the growth of such AMR bacteria through novel mechanisms of action is therefore urgently needed. Here, a new family of indole-containing arene ruthenium organometallic compounds are screened against several bacterial species and drug resistant strains. The most active complex [(p-cym)Ru(O-cyclohexyl-1H-indole-2-carbothioate)Cl] (3) shows growth inhibition and bactericidal activity against different organisms (Acinetobacter baumannii, Mycobacterium abscessus, Mycobacterium tuberculosis, Staphylococcus aureus, Salmonella enterica serovar Typhi and Escherichia coli), demonstrating broad-spectrum inhibitory activity. Importantly, this compound series exhibits low toxicity against human cells. Owing to the novelty of the antibiotic family, their moderate cytotoxicity, and their inhibitory activity against Gram positive, Gram negative and acid-fast, antibiotic resistant microorganisms, this series shows significant promise for further development.

Funding

Royal Society

Understanding the anticancer properties of metal-based drug candidates

Academy of Medical Sciences

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History

Author affiliation

College of Life Sciences/Respiratory Sciences

Version

  • VoR (Version of Record)

Published in

Current Research in Microbial Sciences

Volume

3

Pagination

100099 - 100099

Publisher

Elsevier BV

issn

2666-5174

eissn

2666-5174

Copyright date

2021

Available date

2024-04-23

Spatial coverage

Netherlands

Language

en

Deposited by

Dr Natalie Garton

Deposit date

2024-04-16

Rights Retention Statement

  • No

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