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Interleukin 12p40 is required for dendritic cell migration and T cell priming after Mycobacterium tuberculosis infection

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journal contribution
posted on 2016-01-21, 09:48 authored by S. A. Khader, S. Partida-Sanchez, G. Bell, D. M. Jelley-Gibbs, S. Swain, John Edward Pearl, N. Ghilardi, F. J. Desauvage, F. E. Lund, A. M. Cooper
Migration of dendritic cells (DCs) to the draining lymph node (DLN) is required for the activation of naive T cells. We show here that migration of DCs from the lung to the DLN after Mycobacterium tuberculosis (Mtb) exposure is defective in mice lacking interleukin (IL)-12p40. This defect compromises the ability of IL-12p40-deficient DCs to activate naive T cells in vivo; however, DCs that express IL-12p40 alone can activate naive T cells. Treatment of IL-12p40-deficient DCs with IL-12p40 homodimer (IL-12(p40)(2)) restores Mtb-induced DC migration and the ability of IL-12p40-deficient DCs to activate naive T cells. These data define a novel and fundamental role for IL-12p40 in the pathogen-induced activation of pulmonary DCs.

History

Citation

Journal of Experimental Medicine, 2006, 203 (7), pp. 1805-1815

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Infection, Immunity and Inflammation

Version

  • VoR (Version of Record)

Published in

Journal of Experimental Medicine

Publisher

Rockefeller University Press

issn

0022-1007

eissn

1540-9538

Acceptance date

2006-06-06

Copyright date

2006

Available date

2016-01-21

Publisher version

http://jem.rupress.org/content/203/7/1805

Language

en