Interrupting prolonged sitting reduces postprandial GIP but not GLP-1 responses in type 2 diabetes

<p dir="ltr">Glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are two key intestinal-derived incretin hormones with therapeutic potential for glycaemic and weight management.<a href="https://dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/dom.70046#dom70046-bib-0001" target="_blank">¹</a> Postprandial GLP-1 and GIP potentiate insulin secretion from pancreatic beta cells.<a href="https://dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/dom.70046#dom70046-bib-0001" target="_blank">¹</a> In type 2 diabetes (T2D), although the insulinotropic effect of GLP-1 is preserved, GIP exhibits aberrant signalling at beta cells, attenuating insulin secretion.<a href="https://dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/dom.70046#dom70046-bib-0001" target="_blank">¹</a> Breaking up prolonged sitting with brief bouts of activity can improve postprandial glucose, insulin, lipids, and blood pressure responses in T2D<a href="https://dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/dom.70046#dom70046-bib-0002" target="_blank">²</a>^-<a href="https://dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/dom.70046#dom70046-bib-0004" target="_blank">⁴</a>; however, the effect of these behaviours on incretin hormone responses in T2D remains unknown. Given the role of incretin hormones in postprandial glycaemic regulation, we examined the potential acute effects of interrupting prolonged sitting with brief bouts of light-intensity walking (LW) and simple resistance activities (SRA) on postprandial GLP-1 and GIP responses in middle-aged and older females and males with T2D.</p>