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Intestinal Barrier Disturbances in Haemodialysis Patients: Mechanisms, Consequences, and Therapeutic Options

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posted on 2017-03-30, 10:18 authored by D. S. March, M. P. Graham-Brown, C. M. Stover, N. C. Bishop, James O. Burton
There is accumulating evidence that the intestinal barrier and the microbiota may play a role in the systemic inflammation present in HD patients. HD patients are subject to a number of unique factors, some related to the HD process and others simply to the uraemic milieu but with common characteristic that they can both alter the intestinal barrier and the microbiota. This review is intended to provide an overview of the current methods for measuring such changes in HD patients, the mechanisms behind these changes, and potential strategies that may mitigate these modifications. Lastly, intradialytic exercise is an increasingly employed intervention in HD patients; however the potential implications that this may have for the intestinal barrier are not known; therefore future research directions are also covered.

History

Citation

BioMed Research International , 2017, Article ID 5765417

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Infection, Immunity and Inflammation

Version

  • VoR (Version of Record)

Published in

BioMed Research International

Publisher

Hindawi Publishing Corporation

issn

2314-6133

eissn

2314-6141

Acceptance date

2016-12-20

Copyright date

2017

Available date

2017-03-30

Publisher version

https://www.hindawi.com/journals/bmri/2017/5765417/

Language

en

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