posted on 2015-11-11, 09:47authored byGemma C. Geary, Eric G. Hope, Alison M. Stuart
A new class of fluorinated lactones was prepared by the intramolecular fluorocyclizations of unsaturated carboxylic acids by using the stable fluoroiodane reagent in combination with AgBF4 . This unique reaction incorporates a cyclization, an aryl migration, and a fluorination all in one step. The fluoroiodane reagent, prepared easily from fluoride, can also be used without a metal catalyst to give moderate yields within just 1 hour, thus demonstrating that it is a suitable reagent for developing new (18) F-labelled radiotracers for PET imaging.
History
Citation
Angewandte Chemie International Edition, 2015 (Early View, In press)
Author affiliation
/Organisation/COLLEGE OF SCIENCE AND ENGINEERING/Department of Chemistry
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