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Long-term ocular and visual outcomes following symptomatic and asymptomatic congenital CMV infection: a systematic review protocol

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posted on 2022-07-01, 16:02 authored by Urvi Karamchandani, Umar Ahmed, Sohaib R Rufai, Naomi Tan, Weijen Tan, Harry Petrushkin, Ameenat Lola Solebo

Cytomegalovirus (CMV) is one of the most common congenitally acquired infections worldwide. Visual impairment is a common outcome for symptomatic infants, with long-term ophthalmic surveillance often recommended. However, there are no clear guidelines for ophthalmic surveillance in infants with asymptomatic disease. We aim to conduct a systematic review to establish the overall prevalence and incidence of eye and vision related disorders following congenital CMV infection (cCMV).A systematic review and meta-analysis (pending appropriate data for analysis) of cross-sectional and longitudinal studies will be conducted. The PubMed, Embase and CINAHL databases will be searched up to 29 March 2022 without date or language restrictions. Studies will be screened by at least two independent reviewers. Methodological quality of included studies will be assessed using the Joanna Briggs Institute tool. The primary outcome measures will be incidence and/or prevalence of vision impairment or ophthalmic disorders in patients with symptomatic and asymptomatic cCMV infection. A narrative synthesis will be conducted for all included studies. The overall prevalence will be estimated by pooling data using a random-effects model. Heterogeneity between studies will be estimated using Cochran's Q and the I2 statistics. Egger's test will be used to assess for publication bias.Ethical approval is not required as there is no primary data collection. Study findings will be disseminated at scientific meetings and through publication in peer-reviewed journals.This is not a clinical trial, but the protocol has been registered: CRD42021284678 (PROSPERO).


Funding

ALS is funded by an NIHR Clinician Scientist award (CS-2018-18- ST2-005). SRR is funded by a National Institute for Health Research (NIHR) Doctoral Fellowship (Award ID: NIHR300155). This work took place at Moorfields Eye Hospital and Great Ormond Street Hospital, which receive support from the National Institute for Health Research Biomedical Research Centres (NIHR BRC) based at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, and at Great Ormond Street Hospital. This publication presents independent research funded by the National Institute for Health Research (NIHR).

History

Citation

: Karamchandani U, Ahmed U, Rufai SR, et al. Longterm ocular and visual outcomes following symptomatic and asymptomatic congenital CMV infection: a systematic review protocol. BMJ Open 2022;12:e059038. doi:10.1136/bmjopen-2021-059038

Author affiliation

Ulverscroft Eye Unit

Version

  • VoR (Version of Record)

Published in

BMJ OPEN

Volume

12

Issue

5

Pagination

(5)

Publisher

BMJ PUBLISHING GROUP

issn

2044-6055

eissn

2044-6055

Acceptance date

2022-04-27

Copyright date

2022

Available date

2022-07-01

Spatial coverage

England

Language

English

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