14-0060.R2_MAIN+DOC+%28SD_CM%29_v2.2.pdf (286.09 kB)
Download fileManagement of refractory overactive bladder
journal contribution
posted on 2018-01-15, 15:39 authored by Julie Wong, Douglas G. TincelloKey content
Overactive bladder does not respond to first-line treatment in over 50% of cases.
There is no agreed definition of what constitutes refractory overactive bladder.
Botulinum toxin injection is effective, with a long duration of action but appreciable rates of urinary retention and infection (around 10% and 20%, respectively). There remain some questions about the preferred dose and the schedule of repeat dosing.
There are few data on cost-effectiveness of botulinum toxin.
Sacral nerve stimulation is an invasive, complex and expensive procedure.
Sacral nerve stimulation is effective, but reoperation rates and complications are common.
Percutaneous tibial nerve stimulation is a less invasive, cheaper alternative to sacral nerve stimulation but long-term efficacy is yet to be confirmed.
Learning objectives
To understand the available data on the efficacy and safety of botulinum toxin use.
To be aware of the need for thorough assessment of patients, and the importance of multidisciplinary team review and appropriate detailed counselling.
To understand the available data on the efficacy and safety of the alternative methods of neuromodulation.
Ethical issues
The long-term benefits and risks of these treatments are not fully defined. Is it ethical to commence potentially lifelong treatment without robust, high-quality data confirming safety?
History
Citation
Obstetrician and Gynaecologist, 2016, 18 (3), pp. 173-181 (9)Author affiliation
/Organisation/COLLEGE OF LIFE SCIENCES/School of Medicine/Department of Health SciencesVersion
- AM (Accepted Manuscript)
Published in
Obstetrician and GynaecologistPublisher
Wiley for Royal College of Obstetricians and Gynaecologistseissn
1744-4667Acceptance date
2015-10-09Copyright date
2016Available date
2018-01-15Publisher DOI
Publisher version
http://onlinelibrary.wiley.com/doi/10.1111/tog.12265/abstractLanguage
enAdministrator link
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Keywords
Science & TechnologyLife Sciences & BiomedicineObstetrics & Gynecologybotulinum toxindetrusor overactivityneuromodulationoveractive bladdersacral nervetibial nerveBOTULINUM-TOXIN-APLACEBO-CONTROLLED TRIALURINARY URGE INCONTINENCESACRAL NERVE-STIMULATIONIDIOPATHIC DETRUSOR OVERACTIVITYQUALITY-OF-LIFEDOUBLE-BLINDINTRADETRUSOR INJECTIONSONABOTULINUM TOXINSINGLE-CENTER