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Develop Med Child Neuro - 2021 - Jaekel - Mathematical performance in childhood and early adult outcomes after very preterm.pdf (448.7 kB)

Mathematical performance in childhood and early adult outcomes after very preterm birth: an individual participant data meta-analysis

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journal contribution
posted on 2021-12-22, 16:39 authored by Julia Jaekel, Peter J Anderson, Jeanie Cheong, Lex Doyle, Samantha Johnson, Neil Marlow, Saroj Saigal, Louis Schmidt, Mary Sullivan, Dieter Wolke
Aim
To investigate the strength of the independent associations of mathematics performance in children born very preterm (<32wks' gestation or <1500g birthweight) with attending postsecondary education and their current employment status in young adulthood.

Method
We harmonized data from six very preterm birth cohorts from five different countries and carried out one-stage individual participant data meta-analyses (n=954, 52% female) using mixed effects logistic regression models. Mathematics scores at 8 to 11 years of age were z-standardized using contemporary cohort-specific controls. Outcomes included any postsecondary education, and employment/education status in young adulthood. All models were adjusted for year of birth, gestational age, sex, maternal education, and IQ in childhood.

Results
Higher mathematics performance in childhood was independently associated with having attended any postsecondary education (odds ratio [OR] per SD increase in mathematics z-score: 1.36 [95% confidence interval {CI}: 1.03, 1.79]) but not with current employment/education status (OR 1.14 per SD increase [95% CI: 0.87, 1.48]).

Interpretation
Among populations born very preterm, childhood mathematics performance is important for adult educational attainment, but not for employment status.

Funding

Australian Medical Research Future Fund. Grant Number: Career Development Fellowship #1141354

Australian National Health and Medical Research Council (NHMRC). Grant Number: Investigator Grant #1176077

Australian NHMRC. Grant Number: #1104300, #491246

Canadian Institutes of Health Research (CIHR). Grant Number: Team Grant 2009H00529

EU Horizon 2020. Grant Number: 733280 (RECAP-preterm)

German Research Foundation (DFG). Grant Number: JA 1913/2-2

Hospital for Sick Children Foundation, Toronto, Ontario. Grant Number: ESPM85-201

Medical Research Council. Grant Number: MR/N024869/1

National Institutes of Health (NIH), National Institute of Nursing Research. Grant Numbers: R01 NR 003695-01, R01 NR003695-14

New Opportunities for Research Funding Agency Co-operation in Europe (NORFACE), Dynamics of Inequality Across the Life-course Program. Grant Number: 462-16-040

NHIR Biomedical Research Centre at UCL/UCLH

History

Citation

Developmental Medicine and Child Neurology, 2021, https://doi.org/10.1111/dmcn.15132

Author affiliation

Department of Health Sciences, University of Leicester

Version

  • VoR (Version of Record)

Published in

Developmental Medicine and Child Neurology

Publisher

Wiley

issn

0012-1622

Acceptance date

2021-11-12

Copyright date

2021

Available date

2021-12-22

Language

en

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