University of Leicester
Browse
e003032.full.pdf (2.06 MB)

Matter of TIME: The tumor-immune microenvironment of mesothelioma and implications for checkpoint blockade efficacy

Download (2.06 MB)
journal contribution
posted on 2024-02-08, 14:46 authored by J Harber, T Kamata, C Pritchard, D Fennell
Malignant pleural mesothelioma (MPM) is an incurable cancer with a dismal prognosis and few effective treatment options. Nonetheless, recent positive phase III trial results for immune checkpoint blockade (ICB) in MPM herald a new dawn in the fight to advance effective treatments for this cancer. Tumor mutation burden (TMB) has been widely reported to predict ICB in other cancers, but MPM is considered a low-TMB tumor. Similarly, tumor programmed death-ligand 1 (PD-L1) expression has not been proven predictive in phase III clinical trials in MPM. Consequently, the precise mechanisms that determine response to immunotherapy in this cancer remain unknown. The present review therefore aimed to synthesize our current understanding of the tumor immune microenvironment in MPM and reflects on how specific cellular features might impact immunotherapy responses or lead to resistance. This approach will inform stratified approaches to therapy and advance immunotherapy combinations in MPM to improve clinical outcomes further.

History

Author affiliation

Cancer Research Centre, University of Leicester

Version

  • VoR (Version of Record)

Published in

Journal for ImmunoTherapy of Cancer

Volume

9

Issue

9

Pagination

e003032

Publisher

BMJ

eissn

2051-1426

Copyright date

2021

Available date

2024-02-07

Language

en

Usage metrics

    University of Leicester Publications

    Categories

    Licence

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC