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Measuring pressure during coronary artery angiography in ex-vivo Hearts

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posted on 2016-02-08, 09:33 authored by Claire Robinson, Asif K. Adnan, David Adlam, Mike Biggs, Guy Nathan Rutty, Bruno Morgan
Coronary artery disease (CAD) is the most common cause of sudden adult death. Diagnosis in life and after death is therefore crucial, but can be problematic and inaccurate. Post-mortem CT angiography (PMCTA) is attempting to address this, but its accuracy is still not fully established. In clinical practice, pressure measurements, recording drops in pressure across the stenosis, are now being used to determine physiological significance, as the degree of narrowing on imaging can be misleading. This study was designed to investigate the introduction of pressure measurement to PMCTA in order to understand the importance of re-pressurising vessels in the evaluation of CAD. Ex-vivo porcine hearts were used to develop the technique. Methods to introduce catheters and wires were investigated and a system was developed to suspend the heart, to enable pressure tests and CT scans. Consistent measurable pressures were achieved with good correlation of measured arterial pressure to delivered pressure in most cases. Pressure measurements were shown to be inaccurate in decomposed hearts, poor dissection and cannulation damaging the vessel, contamination of the vessels (e.g. by air) and malposition of the pressure measurement wire.

History

Citation

Journal of Forensic Radiology and Imaging, 2016, 4, pp. 58-62

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Cancer Studies and Molecular Medicine

Version

  • AM (Accepted Manuscript)

Published in

Journal of Forensic Radiology and Imaging

Publisher

Elsevier

issn

2212-4780

Acceptance date

2015-11-07

Copyright date

2015

Available date

2016-11-12

Publisher version

http://www.sciencedirect.com/science/article/pii/S2212478015300307

Notes

The file associated with this record is under a 12-month embargo from publication in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.

Language

en

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