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Metabolomic biomarkers and novel dietary factors associated with gestational diabetes in China

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posted on 2019-02-14, 10:28 authored by X Chen, JV de Seymour, T-L Han, Y Xia, C Chen, T Zhang, H Zhang, PN Baker
Introduction Gestational diabetes mellitus (GDM) is impaired glucose tolerance first recognised during pregnancy; its development is associated with many adverse outcomes. Mechanisms of GDM development are not fully elucidated and few studies have used Chinese participants. Objectives The aim of this study was to investigate the maternal metabolome associated with GDM in a Chinese population,and explore the relationship with maternal diet. Methods Ninety-three participants were recruited at 26–28 weeks’ gestation from Chongqing, China. Maternal urine, serum, and hair metabolomes were analysed using gas and liquid chromatography–mass spectrometry. Dietary intake was assessed using a 96-item food frequency questionnaire. Results Of the 1064 metabolites identified, 73 were significantly different between cases and controls (P<0.05), but only 2-aminobutyric acid had both a p- and q-value<0.05. A “snack-based-dietary-pattern” was associated with an increased likelihood of GDM (odds ratio 2·1; 95% confidence interval 1.1–3.9). The association remained significant after adjustment for calorie intake but not food volume. Conclusion This study provides a comprehensive characterization of the maternal metabolome. The snack-based dietary pattern associated with GDM suggests that timing and frequency of consumption are important factors in the relationship between maternal diet and GDM.

Funding

This work was supported by the National Natural Science Foundation of China [Grant Nos. 81571453, 81771607, 81701477, 81650110522] and The 111 Project [Grant No. Yuwaizhuan (2016)32].

History

Citation

METABOLOMICS, 2018, 14 (11), pp. ?-? (11)

Author affiliation

/Organisation/COLLEGE OF LIFE SCIENCES

Version

  • AM (Accepted Manuscript)

Published in

METABOLOMICS

Publisher

Springer Verlag for Metabolomics Society

issn

1573-3882

eissn

1573-3890

Acceptance date

2018-10-11

Copyright date

2018

Publisher version

https://link.springer.com/article/10.1007/s11306-018-1445-6

Notes

The file associated with this record is under embargo until 12 months after publication, in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.

Language

en

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