Metabolomics of Pregnancy Complications: Emerging Application of Maternal Hair.pdf (888.39 kB)
Metabolomics of Pregnancy Complications: Emerging Application of Maternal Hair.
journal contributionposted on 2019-09-23, 14:19 authored by TDJ Delplancke, Y Wu, T-L Han, LR Joncer, H Qi, C Tong, PN Baker
In recent years, the study of metabolomics has begun to receive increasing international attention, especially as it pertains to medical research. This is due in part to the potential for discovery of new biomarkers in the metabolome and to a new understanding of the "exposome", which refers to the endogenous and exogenous compounds that reflect external exposures. Consequently, metabolomics research into pregnancy-related issues has increased. Biomarkers discovered through metabolomics may shed some light on the etiology of certain pregnancy-related complications and their adverse effects on future maternal health and infant development and improve current clinical management. The discoveries and methods used in these studies will be compiled and summarized within the following paper. A further focus of this paper is the use of hair as a biological sample, which is gaining increasing attention across diverse fields due to its noninvasive sampling method and the metabolome stability. Its significance in exposome studies will be considered in this review, as well as the potential to associate exposures with adverse pregnancy outcomes. Currently, hair has been used in only two metabolomics studies relating to fetal growth restriction (FGR) and gestational diabetes mellitus (GDM).
This work was supported by the National Key Research and Development Program of Reproductive Health & Major Birth Defects Control and Prevention (2016YFC1000407), the National Natural Science Foundation of China (81520108013, 81671488, and 81871189), Chongqing Municipal Education Commission (CXTDX201601014), Science and Technology Commission of Chongqing (cstc2017jcyjBX0045), and Chongqing Entrepreneurship and Innovation Supporting Program for Returned Overseas Students (cx2017104).
CitationBioMed Research International, 2018, Volume 2018, Article ID 2815439, 19 pages
Author affiliation/Organisation/COLLEGE OF LIFE SCIENCES
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