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Microbially Derived P═S and P═Se Bond Formation

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posted on 2025-05-06, 15:08 authored by Connor L Trotter, Yuta Era, Rory Gordon, Samantha Law, Christopher SwitzerChristopher Switzer, Stephen Wallace
Microbial metabolism is a diverse and sustainable source of synthetic reagents that can be programmed for controlled and high-level production via synthetic biology. However, despite the chemical diversity of metabolism, the chemical utility of metabolites, and the available tools to control metabolic chemistry, there remain few examples of the use of cellular metabolites directly for chemical synthesis. Herein, we report that diverse bacteria perform P═S bond formation (Ph3P to Ph3PS) via central sulfur metabolism and nonenzymatic chemistry in vivo, which can also be applied to affect microbial P═Se bond formation (Ph3PSe). To the best of our knowledge, this is the first biochemical and genetic investigation of P═S bond formation in a microbial cell and the first use of microbial metabolites for P═Se bond formation in chemical synthesis.

History

Author affiliation

College of Life Sciences Molecular & Cell Biology

Version

  • VoR (Version of Record)

Published in

JACS Au

Volume

5

Issue

4

Publisher

American Chemical Society (ACS)

issn

2691-3704

eissn

2691-3704

Copyright date

2025

Available date

2025-05-06

Language

en

Deposited by

Dr Christopher Switzer

Deposit date

2025-04-20

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