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Migraine phenotype differentially modulates the attentional network: A cross sectional observation study

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posted on 2023-07-27, 08:33 authored by AN Bonsu, Z Britton, Z Asif, M Sharif, D Kaski, A Kheradmand, AM Bronstein, Q Arshad
Background: Signs of distinct brain dysfunction in patients where migraine intersects with vertigo (i.e. vestibular migraine (VM)), remain elusive. As migraine and vertigo can both independently modulate attentional processes, here we seek the utility of the attentional network to functionally differentiate patients. Methods: We used the Attentional Network Task (ANT) to elucidate three separate functional networks: Alerting, orienting and resolving conflict. 120 participants had to attend to the direction of a target visual stimulus, while other parameters were simultaneously manipulated. Reaction times across the networks were assessed in, (i) 30 healthy controls, (ii) 30 VM patients, (iii) 30 patients with migraine without vertigo, and (iv) 30 patients with benign paroxysmal positional vertigo (BPPV) but no migraine. Results: Patients with VM (mean = 737.1 ms, SEM = 28), migraine (mean = 735.3 ms, SEM = 36.4), and BPPV (mean = 720.3 ms SEM = 24.3) all exhibited significantly delayed ANT reaction times compared to healthy controls (mean = 661.3 ms, SEM = 23.4). Specific attentional network deficits were observed for resolving conflict in VM, alerting in migraine and orienting in BPPV. Conclusion: VM patients displayed deficits in executive function characterized by an inability to focus attentional resources and suppress peripheral distractors, whereas migraineurs without vertigo exhibited changes in the alerting network that reflects hypervigilance.

Funding

This study was supported by the National Institute for Health Research (NIHR) Imperial Biomedical Research Centre and the National Institute for Health (NIH). The work was also supported by the Grant R01DC018815 from the National Institute on Deafness and other Communication Disorders.

History

Author affiliation

Department of Neuroscience, Psychology and Behaviour, University of Leicester

Version

  • VoR (Version of Record)

Published in

Cephalalgia Reports

Volume

5

Pagination

251581632211242

Publisher

SAGE Publications

issn

2515-8163

eissn

2515-8163

Copyright date

2022

Available date

2023-07-27

Language

en

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