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Mixed mu-nociceptin/orphanin FQ opioid receptor agonists and the search for the analgesic holy grail

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Version 2 2021-09-08, 14:12
Version 1 2019-04-12, 10:31
journal contribution
posted on 2021-09-08, 14:11 authored by D Lambert
Is the search for more highly selective MOP (mu; µ) receptor ligands over ? Do we need more morphine like molecules; fentanyl, oxycodone and the like ? These molecules produce analgesia and are the gold standard against which all analgesics are compared. Sadly, these clinically essential drugs are now better known for their adverse events; on the patient, the misuser and on society. The adverse events associated with opioid use (and misuse) are significant and many. These include respiratory depression, nausea and vomiting, pruritis, gastro intestinal (GI) immobility, immune suppression, tolerance and abuse potential. In some settings, such as palliative care, the adverse events driven by a vicious cycle of dose escalation to titrate effective analgesia begin to outweigh the benefits e.g. when considering GI-immobility; constipation. Designing out these side effects whilst maintaining analgesic efficacy is the challenge for modern experimental pharmacology in alliance with clinical pharmacology (anaesthesia); our Holy Grail.

Funding

Research on opioids in the laboratory of DGL is funded by Biotechnology and Biological Sciences Research Council (BBSRC), British Journal of Anaesthesia and British Heart Foundation

History

Citation

British Journal of Anaesthesia, Volume 122, Issue 6, June 2019, Pages e95-e97

Alternative title

Mixed MOP-NOP opioid agonists and the search for the analgesic holy grail

Author affiliation

/Organisation/COLLEGE OF LIFE SCIENCES/School of Medicine/Department of Cardiovascular Sciences

Version

  • AM (Accepted Manuscript)

Published in

British Journal of Anaesthesia

Volume

122

Issue

6

Pagination

e95-e97

Publisher

Elsevier

issn

0007-0912

eissn

1471-6771

Acceptance date

2019-02-20

Copyright date

2019

Available date

2021-09-08

Language

en

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