University of Leicester
Browse
Moderate increases in daily step count are associated with reduced IL6 and CRP in women with PCOS.pdf (361.69 kB)

Moderate increases in daily step count are associated with reduced IL6 and CRP in women with PCOS.

Download (361.69 kB)
journal contribution
posted on 2019-09-04, 14:07 authored by MA Webb, H Mani, SJ Robertson, HL Waller, DR Webb, CL Edwardson, DH Bodicoat, T Yates, K Khunti, MJ Davies
Aims Physical activity has been proposed to be an effective non-pharmacological method of reducing systemic inflammation and therefore may prove particularly efficacious for women with polycystic ovary syndrome (PCOS) who have been shown to have high levels of inflammation and an increased risk of type 2 diabetes (T2DM) and cardiovascular disease (CVD). Therefore, the aim of the present study was to assess whether modest changes in daily step count could significantly reduce levels of inflammatory markers in women with PCOS. Subjects and Methods Sixty-five women with PCOS were assessed at baseline and again at 6 months. All had been provided with an accelerometer and encouraged to increase activity levels. Multivariate linear regression analyses (adjusted for age, ethnicity, baseline step count, change in BMI and change in accelerometer wear-time) were used to assess changes in daily step count against clinical and research biomarkers of inflammation, CVD and T2DM. Results Mean step count/day at baseline was 6337 (±270). An increase in step count (by 1000 steps) was associated with a 13% reduction in IL6 (β: -0.81 ng/L; 95% CI, -1.37, -0.25, P = 0.005) and a 13% reduction in CRP (β: -0.68 mg/L; 95% CI, -1.30, -0.06, P = 0.033). Additionally, there was a modest decrease in BMI (β: 0.20 kg/m2; 95% CI, -0.38, -0.01, P = 0.038). Clinical markers of T2DM and CVD were not affected by increased step count. Conclusions Modest increases in step count/day can reduce levels of inflammatory markers in women with PCOS, which may reduce the future risk of T2DM and CVD.

Funding

This research was supported by the National Institute for Health Research (NIHR) Leicester Biomedical Research Centre, the NIHR Collaboration for Leadership in Applied Health Research and Care – East Midlands (NIHR CLAHRC – EM) and an Early Career Grant from the Society for Endocrinology (Dr Hamid Mani). The views expressed are those of the authors and not necessarily those of the above mentioned organisations.

History

Citation

Endocrine Connections, 2018, 7 (12), pp. 1442-1447

Author affiliation

/Organisation/COLLEGE OF LIFE SCIENCES/School of Medicine/Diabetes Research Centre

Version

  • VoR (Version of Record)

Published in

Endocrine Connections

Publisher

BioScientifica, European Society of Endocrinology, Society for Endocrinology

issn

2049-3614

Acceptance date

2018-11-21

Copyright date

2018

Available date

2019-09-04

Publisher version

https://ec.bioscientifica.com/view/journals/ec/7/12/EC-18-0438.xml

Language

en

Usage metrics

    University of Leicester Publications

    Categories

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC