Monitoring cerebral hemodynamics in COVID-19 patients in the prone position

Prone positioning (PP) has been used in Acute Respiratory Distress Syndrome (ARDS), including patients with COVID-19 [1]. While it improves oxygenation, the impact of PP on cerebral hemodynamics remains controversial [2,3]. Of considerable relevance, patients with COVID-19 have shown a high incidence of delirium and neurological complications, that could suggest involvement of cerebral autoregulation (CA) [4]. Above all, it is not clear how CA is affected by PP in patients with COVID-19. In a pilot prospective study, we tested the feasibility of continuously monitoring key cerebral hemodynamic parameters in COVID-19 patients undergoing PP. [Opening paragraph]