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Mutation induction in humans and mice: where are we now?

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journal contribution
posted on 2020-04-23, 10:47 authored by Y Dubrova
The analysis of mutation induction in human families exposed to mutagens provides the only source of reliable estimates of factors contributing to the genetic risk of human exposure to mutagens. In this paper, I briefly summarize the results of recent studies on the pattern of mutation induction in the human and mouse germline. The results of recent studies on the genome-wide effects of exposure to mutagens on mutation induction in the mammalian germline are presented and discussed. Lastly, this review also addresses the issue of transgenerational effects of parental exposure to mutagens on mutation rates in their non-exposed offspring, which are known as transgenerational instability. The possible contribution of transgenerational instability to the genetic risk of human exposure to mutagens is discussed.

Funding

The British Nuclear Test Veterans Association, grant number 215695, funded this research.

History

Citation

Cancers, 2019, Vol. 11 (11), 1708

Author affiliation

Department of Genetics and Genome Biology

Version

  • VoR (Version of Record)

Published in

Cancers

Volume

11

Issue

11

Pagination

1708 - 1708

Publisher

MDPI

issn

2072-6694

eissn

2072-6694

Acceptance date

2019-10-30

Copyright date

2019

Publisher version

https://www.mdpi.com/2072-6694/11/11/1708/htm

Language

en

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